Authors: Demet Tok, MD, Ozer Ilkgul, MD, Stig Bengmark, MD, PhD, Hasan Aydede, MD, Yamac Erhan, MD, Fatma Taneli, MD, Cevval Ulman, MD, Seda Vatansever, MD, Can Kose, MD, and Gulay Ok, MD.
Published: The Journal of TRAUMA Injury, Infection, and Critical Care, 2007;62..
The study was conducted in vivo, involving animals.
Design: Randomly selected and divided.
Treatment: Rats were divided into five groups, and subjected to induction of peritonitis-induced lung injury. All animals were pretreated for 3 weeks prior with either (1) a synbiotic composition (2) fermentable fibers alone, (3) nonfermentable fibers, (4) a probiotic composition or (5) a heat-killed probiotic composition. (s. 880).
Where and when: Ege University Faculty of Medicine, Experimental Animal Research Laboratory.
Sample size: 50 rats.
Sample criteria: Fifty male adult Wistar albino rats weighing 250 to 300 g were randomly selected.
Analysed material: Lung tissue samples.
Results
Signs of lung injury were observed in all groups except the synbiotic and probiotic treated groups.
Heavy infiltration of lung tissue with neutrophils was observed only in fiber treated and placebo-treated animals. This was totally abolished in the synbiotic-treated group. Lung edema was significantly reduced in the symbiotic-treated group. (s. 880).
Indicative results
Three weeks of preoperative enteral administration of a synbiotic composition reduced peritonitis-induced acute lung injury in rats in a CLP model. (s. 880).
Bacteremia after CLP reduction by 50% and endotoxins reduction by 47% after 24 hours in the LAB-pretreated rats, in sharp contrast to gentamycin, which had no effect, has been documented. Also it has been documented that Intestinal transit significantly enhanced synbiotic-treated animals. The normal flora has pronounced effects on numerous body functions, including regulation of gastrointestinal motility, various immune functions, and resistance to diseases (s. 883).
Synbiotic treatment as a promising alternative needs further exploration. It has significant efficacy without side effects and can be provided at limited costs.
To pretreat for a period as long as 3 weeks, as done in this experimental study, might not be necessary. In emergency situations, pretreatment is not possible. Also enteral supply is not always possible. Parenteral supply might in such situations offer a better alternative. Future studies are necessary to elucidate that. (s. 884).
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